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1994-10-25
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Document 2900
DOCN M94A2900
TI Outbreak of CNS toxoplasmosis due to AIDS in Bombay.
DT 9412
AU Lanjewar DN; Dept. of Pathology, Grant Medical College, Bombay, India.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):199 (abstract no. PB0223). Unique
Identifier : AIDSLINE ICA10/94369675
AB OBJECTIVE: To determine the incidence of CNS opportunistic infection
among patients with AIDS. METHODS: Forty cases of AIDS were included in
autopsy study. Examination of brain was carried out by H & E stain.
Special stains were carried out for tubercle bacilli, fungal infection
and myelin fibres. RESULTS: Morphologic lesions in brain were identified
in 17 of 40 cases (42.5%). Acute encephalitis caused by T.gondii was
diagnosed in 10 cases (25%). These lesions comprised of ischemic
necrosis, vasculitis, vascular thrombi, hypertrophic occlusive arteritis
and presence of free and cyst form of T. gondii in brain. The imprint
smear cytology of necrotic lesions in brain also showed free forms of T.
gondii. Other opportunistic infections were cryptococcosis (3 cases),
candidiasis (1 case) TB meningitis and tuberculoma (1 case each) and
pyogenic meningitis (1 case). CONCLUSION: CNS toxoplasmosis is the
commonest opportunistic infection in AIDS patients of Bombay. All cases
of CNS toxoplasmosis were not suspected antemortem which emphasize the
necessity of including toxoplasmosis in differential diagnosis of
encephalitis in patients with AIDS.
DE AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/MICROBIOLOGY/
PARASITOLOGY Candidiasis/EPIDEMIOLOGY *Disease Outbreaks
Encephalitis/*EPIDEMIOLOGY/MICROBIOLOGY/PARASITOLOGY Human
India/EPIDEMIOLOGY Meningitis, Cryptococcal/EPIDEMIOLOGY
Toxoplasmosis, Cerebral/*EPIDEMIOLOGY Tuberculoma/EPIDEMIOLOGY
Tuberculosis, Meningeal/EPIDEMIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).